Lipedema and DVT: What are the Similarities and Differences?

Written By Center for Vein Restoration
Blog Lipedema DVT

Lipedema and deep vein thrombosis (DVT) are two medical conditions that can affect the circulatory system, but they have distinct characteristics and treatments. While they may share some similarities, understanding the differences between these conditions is crucial for accurate diagnosis and appropriate management.

What is Lipedema?

Lipedema is a chronic condition characterized by an abnormal accumulation of fat in the legs and sometimes the arms, leading to pain, swelling, and other symptoms. The exact cause of lipedema is not fully understood, but it is believed to involve a combination of genetic, hormonal, and environmental factors. Here are some key points about the potential causes:

  1. Genetics: Lipedema often runs in families, suggesting a genetic component. Some studies have identified specific genes that may be associated with the development of lipedema.
  2. Hormonal Factors: Hormonal changes, such as those that occur during puberty, pregnancy, or menopause, can influence the development and progression of lipedema. Estrogen is thought to play a role in the condition, as it can promote fat storage and fluid retention.
  3. Inflammation: Some researchers believe that inflammation may contribute to the development and progression of lipedema. Chronic inflammation in the body could lead to changes in fat tissue distribution and fluid retention.
  4. Lifestyle and Diet: While not a direct cause, lifestyle factors such as poor diet and lack of physical activity may exacerbate the symptoms of lipedema. Maintaining a healthy lifestyle can help manage the condition.

It's essential to consult a healthcare professional for a proper diagnosis and discuss potential treatment options.

What is Deep Vein Thrombosis?

Deep Vein Thrombosis (DVT) is a medical condition characterized by the formation of blood clots, known as thrombi, within the body's deep veins, typically in the legs. These clots can obstruct or partially block the blood flow through the affected veins, causing a range of potentially serious health problems. DVT is a significant concern because it can lead to life-threatening complications if not diagnosed and treated promptly.

The primary cause of DVT is venous stasis, which occurs when blood flow slows down or becomes stagnant, often due to prolonged immobility, surgery, injury, or certain medical conditions. Other risk factors include a history of DVT, family history of blood clots, pregnancy, oral contraceptive use, obesity, smoking, and certain genetic conditions that affect blood clotting.

The most concerning complication of DVT is when a piece of the clot, called an embolus, breaks off and travels through the bloodstream. If the embolus reaches the lungs, it can cause a pulmonary embolism (PE), a life-threatening condition that interferes with oxygen exchange in the lungs.

What are the symptoms of DVT?

Symptoms of DVT can include pain, swelling, warmth, and redness in the affected leg. However, some people may not experience noticeable symptoms, making early detection challenging. Diagnosis typically involves ultrasound imaging.

What is the treatment for DVT?

Treatment for DVT often includes anticoagulant medications (blood thinners) to prevent the clot from growing and to reduce the risk of further clots. In some cases, more invasive procedures may be necessary to remove or dissolve the clot. It is crucial to seek immediate medical attention if DVT is suspected to prevent potentially lethal complications and ensure proper management.

Similarities Between Lipedema and DVT

The Circulatory System: Both lipedema and DVT involve the circulatory system. Understanding how these conditions affect blood flow is essential to recognize their similarities.

Leg Swelling: One of the most apparent similarities between lipedema and DVT is leg swelling. In both cases, individuals may experience swelling in their legs, ranging from mild to severe.

Pain and Discomfort: Individuals with lipedema and DVT often experience pain and discomfort in their legs. This discomfort can vary in intensity and may include sensations of heaviness, aching, or tenderness.

Risk Factors: Some common risk factors are associated with both conditions. These include obesity, hormonal changes (such as during pregnancy or menopause), and a family history of circulatory issues.

Differences Between Lipedema and DVT

Underlying Causes:

Lipedema: Lipedema is primarily a genetic disorder that affects the distribution of fat in the body. It occurs almost exclusively in women and typically begins during puberty or pregnancy.

DVT: Deep Vein Thrombosis is a condition characterized by the formation of blood clots in deep veins, most commonly in the legs. It can occur in both men and women and is often associated with factors like prolonged immobility, surgery, or trauma.

Fat Accumulation vs. Blood Clots:

Lipedema: Lipedema leads to abnormal fat accumulation, primarily in the legs and sometimes in the arms. This excess fat is often resistant to diet and exercise.

DVT: DVT involves the formation of blood clots within the deep veins, obstructing normal blood flow. These clots can potentially break loose and travel to the lungs, causing a life-threatening condition called pulmonary embolism.


Lipedema: Diagnosis of lipedema typically involves a physical examination by a healthcare provider who is familiar with the condition. Imaging studies like ultrasound or MRI may be used to rule out other conditions.

DVT: Diagnosis of DVT often requires specialized tests such as Doppler ultrasound, which can detect the presence of blood clots in the deep veins. Blood tests to measure specific clotting factors may also be used.


Lipedema: Treatment for lipedema focuses on managing symptoms and improving quality of life. Conservative approaches include compression garments, manual lymphatic drainage, and lifestyle modifications. In some cases, surgical interventions like liposuction may be considered to reduce the excessive fat deposits.

DVT: Treatment for DVT is more urgent and aims to prevent complications like pulmonary embolism. It typically involves anticoagulant medication (blood thinners) to dissolve or prevent the growth of blood clots. Compression stockings may also be recommended to alleviate leg swelling.


Lipedema: Lipedema is a chronic condition, but it is not life-threatening. With proper management, individuals can lead fulfilling lives and minimize the progression of symptoms.

DVT: DVT can be life-threatening if left untreated, as it can lead to pulmonary embolism. However, with prompt diagnosis and appropriate treatment, the prognosis is generally favorable.


Lipedema: There is no known way to prevent lipedema, as it is primarily influenced by genetic factors.

DVT: Preventing DVT involves reducing risk factors, such as maintaining a healthy weight, staying physically active, avoiding prolonged immobility (especially during long flights or bed rest after surgery), and following medical advice if you have a family history of blood clotting disorders.

In conclusion, while lipedema and DVT share some similarities, such as leg swelling and discomfort, they have distinct causes, diagnostic methods, treatments, and prognoses. Lipedema primarily involves abnormal fat accumulation and is a chronic condition that affects mostly women. On the other hand, DVT results from blood clot formation and can affect both genders, posing a greater risk to life if not promptly treated.

What to Do If You Suspect Lipedema or DVT

It's essential to consult a healthcare professional for an accurate diagnosis if you experience symptoms related to either condition. Early detection and appropriate management are critical for minimizing the impact of these conditions on your health and well-being.

If you suspect DVT, seek medical attention promptly to receive the appropriate care and guidance for your specific condition. CVR offers a DVT rule-out service for same-day or next-day diagnosis and treatment plan options. Our hotline number is 877-SCAN-DVT.

If you suspect lipedema, call 240-965-3915 to speak to a Patient Services Representative about scheduling with a CVR physician near you to address your lipedema concerns.

Trust the physicians at Center for Vein Restoration with your leg health

The board-certified physicians at Center for Vein Restoration (CVR) are experts in diagnosing and treating vein disease. As America’s largest physician-led vein center, CVR is your go-to expert for caring for your complete leg health.

If your legs ache, throb, feel heavy, or you have uncomfortable or unsightly varicose veins or spider veins, call 240-965-3915 to speak to a Patient Services Representative or schedule your consultation online at a CVR near you today. CVR accepts many insurances, including Aetna, Amerigroup, Anthem, Blue Cross/Blue Shield, Cigna, MultiPlan, Medicaid, Medicare, and more.

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